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doi:10.1093/jn/133.11.3972S

Data from behavioral studies using scopolamine amnesia and aged rat models, where dihexa was able to reverse cognitive deficits, indicated that the metabolic stability and BBB permeability of dihexa was apparently high enough to attain therapeutic brain levels after oral administration

The + 4-oxidation state of Mn in MnO imparts strong oxidative properties, enabling its responsiveness to reducing agents like GSH, allowing it to be rapidly reduced and degraded by GSH